Current Issue : July - September Volume : 2013 Issue Number : 3 Articles : 7 Articles
Present study investigated the antiobesity potential of Lagenaria siceraria fruit juice in diet - induced obese animals, owing to its traditional use in treatment of hyperlipidaemia and obesity. Initial four weeks, animals were given high - fat diet to render them obese, which was confirmed by significant increase in body weight, Lee index and increased total cholesterol, total triglycerides and LDL cholesterol levels. Obese rats were administered freeze dried juice (250 and 500 mg/kg body weight) orally for next four weeks, with or without high - fat diet. Sibutramine (10mg/kg) was used as positive control. Food consumption was significantly reduced in treatment groups. At the end of treatment, significant fall in total cholesterol, total triglycerides, LDL cholesterol was recorded besides significant rise in HDL cholesterol. Liver histopathology of treatment group animals also showed normal architecture of hepatocytes unlike negative control animals. Juice also prevented increase in liver weight and elevation of weights of various body fat depots like abdominal, renal and epididymal. 500 mg/kg dose of dried juice was found to be more promising and its action was almost at par or better than positive control. This study suggests that antiobesity activity of Lagenaria siceraria juice might be through pancreatic lipase inhibitory activity and satiety feeling...
Hypolipidemic effects of germinated seeds of Cicer arientinum L. in ovariectomized rats was evaluated and compared with atorvastatin. Twenty four female wistar rats were divided into four groups i.e., group I control (sham operated), group II ovariectomized rats, group III ovariectomized + Bengalgram and group IV ovariectomized + Atorvastatin (1.2 mg/kg b.wt p.o.). There was a significant (p<0.05) increase in the serum total cholesterol and non-HDL cholesterol in group II. Serum HDL concentrations significantly (p<0.05) increased in groups III and IV. The triglyceride levels were low in group III but significantly (p<0.05) high in group IV. There was a significant (p<0.05) increase in the uterine weights in group III. The liver lipid profile revealed significant (p<0.05) increase in total lipids, total cholesterol and phospholipids in group II and they significantly (p<0.05) decreased in group III....
The anticonvulsant and antioxidant activity was examined against Maximum Electro Shock (45 mA for 0.2 sec) and Pentylenetetrazole (65 mg/kg i.p) induced convulsion in Swiss Albino Mice. Mice of either sex weighing 28 -30 g were pretreated with methanolic extract of Lagenaria siceraria (MELS) for 7 days. Convulsion was induced on 8th day and convulsive parameters of both the models were measured. After that, animals were sacrificed by cervical dislocation, brain was removed for biochemical estimations like lipid peroxidation, glutathione in both the experimental model and brain GABA content in MES induced convulsion. Sleep potentiation activity of MELS was undertaken by using Diazepam (6 mg/kg i.p) for induction of sleep. Induction of convulsion caused significant depletion in, Glutathione (GSH), GABA and significant increase in Malondialdehyde (MDA). MELS (400 mg/kg p.o) showed significant reduction in the duration of HLTE (p< 0.001) in and reduced mortality to 33.33% in MES induced convulsion and also exhibited significant (p < 0.05) reduction in duration in PTZ-induced seizures and reduced mortality to 36.33% respectively. MELS (400 mg/kg p.o) showed significant reduction in MDA and increase in GSH in both the experimental model. Whereas level of GABA was in significantly increased in MES induced convulsion. MELS (25 and 50 mg/kg b.w; i.p.) did not show significant effect on diazepam (6 mg/kg b.w; i.p.) induced sleeping time. The data obtained from the study indicates the anticonvulsant potential of MELS in both the experimental model used....
Evaluation of antiurolithitic activity of ethanolic extract of Cyperus rotundus Linn. rhizome. The antiurolithiatic was activity experimentally evaluated by using poly ethylene glycol (0.75% v/v) induced rats for 28 days. The level of various urolithiatic promoters in the biological samples (urine, serum and kidney homogenate) renal function and histopathology were used as criteria for assessing the antiurolithiatic effect of EECR at a dose of 750 mg/kg produce wistar rats were divided in 4 group (n=6) control, disease control, standard and test. In ethylene glycol induced urolithatic model, EECR showed significant diseases excretion and deposition of various urolithiatic promoters (calcium, oxalate, phosphate and uric acid) as compared to urolithiatic control (p<0.05). EECR also decreased serum concentration of urea, uric acid and creatinine as compared to urolithiatic control (p<0.01). The present study showed that the antiurolithiatic activity of EECR may be mainly due to its diuretic activity. The presence of phytoconstituents like flavanoids, saponins and terpenoids in EECR might be responsible for its antiurolithatic potency of Cyperus rotundus....
Therapeutic usage of some of the Indian herbal medicinal plants for fibrinolytic activity or thrombolytic activity in reducing the incidences of infarction is well known. Present study was carried out to investigate fibrinolytic activity of selected indigenous plants and culinary spices by determining the in-vitro clot lysis potential taking activity of urokinase, a known fibrinolytic enzyme as positive control. Experiments for clot lysis were carried out as described by Prasad(1), et al., (2006) with few modifications. Among the indigenous plants based on the percentage of clot lysis, Gloriosa superba, L. revealed strongest fibrinolytic activity followed by Sesbania grandiflora, L. Pers, Achyranthues aspera, L., Calotropis gigantean, R. Br., Mangifera indica, L., Ancardium occidentale, L. and Amaranthus gangeticus. Among the culinary spices Cuminum cyminum, L. revealed strong fibrinolytic potential followed by Terminalia chebula, Retz., Pimpinella anisum, Illicium verum , Nigella sativa, Linn, Mentha piperata and Myristica fragrans Houtt. The present study revealed the fibrinolytic potential of indigenous plants and culinary spices, to some extent optimistic pointing to the value of further studies in this field....
The antioxidant potential of polyherbal compounds namely, immuplus was assessed for therapeutic management of an experimental model of oxidative stress induced by ochratoxin, at a toxic level of 2.5 ppm in feed. A total of seventy five sexed male broiler chicks (Cobb strain) of day old age were procured for the study. The chicks were randomly divided into five groups consisting of fifteen in each group. Group 1 received normal basal diet from day 1 to 42nd day. Group 2 received Immuplus@ 75 mg/15 birds for 1–4 weeks, 150 mg/15 birds for 5–6 weeks. Group 3 was given Ochratoxin@ 2.5 ppm in feed for 42 days. Group 4 was given Ochratoxin@ 2.5 ppm for first 28 days followed by basal diet from 29–42 days. Group 5 birds received combination of ocharatoxin@ 2.5 ppm upto 42 days from day one and Immuplus@ 75 mg/15 birds for 1–4 weeks, 150 mg/15 birds for 5–6 weeks. Antioxidant defense profile (GSH-Px, GSH-R, catalase) was evaluated in blood and GSH, and TBARS was evaluated in liver. Serum parameters like ALT, BUN and total protein were evaluated as biomarkers of hepatic damage and kidney damage. Antioxidant enzyme levels and biochemical parameters were significantly altered in the ochratoxin toxic control groups. These parameters were normal in the controls (groups 1 and 2 and group 5 that was given immuplus therapeutically....
Anaemia is the most common disorder of the blood. Standard treatment of anaemia with iron supplementation, blood transfusion and the administration of an erythropoiesis-stimulating agent (ESA) has been associated with a number of adverse drug reactions. Herbal drugs are claimed to be safer ones because they have shown a few adverse drug reactions when compared to modern synthetic drugs. This study was conducted to establish the hematopoietic and haematinic potential of Cydonia oblonga in an attempt to seek treatment against anaemia. Hydro-alcoholic extract of Cydonia oblonga (HECO) at the dose of 500 and 800 mg/kg p.o. was given to New Zealand white rabbits. After thirty days of dosing, the effect of the extract on blood cells and liver enzymes was assessed. Results showed that haemoglobin (Hb), RBC count and hematocrit of Cydonia oblonga treated rabbits were increased highly significantly (bp < 0.001) when compared to normal control rabbits. Leukocyte and platelet counts were increased significantly (ap < 0.05). The levels of liver enzymes such as SGPT, SGOT, gamma GT and alkaline phosphatase were insignificantly decreased in both HECO 500 and 800 mg/kg group rabbits when compared with the control rabbits. The results show that HECO has significant hematopoietic and haematinic potential and can safely be used to treat anaemia....
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